Cell-mediated immune response
digital file Black & White Sound 1974 26:48
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Summary: Professor John Turk lectures on cell-mediated immune response, the immune response to infection or alien bodies which is triggered by effector T cells. He describes this complex molecular process using diagrams, charts, histograms and illustrations. 5 segments
Title number: 18344
LSA ID: LSA/21501
Description: Segment 1 Turk introduces the subject, differentiating it from a previous lecture which looked at B-lymphocyte reactions this lecture will focus on T-lymphocyte reactions. He shows a diagram detailing possible changes to bone marrow lymphocytes when affected by T-lymphocytes. Turk then shows a series of tables listing delayed hypersensitivity reactions to microbial protein antigens followed by tables comparing Arthus reactions and tuberculin antigens in terms of their reaction to T-lymphocytes. Time start: 00:00:00:00 Time end: 00:06:51:00 Length: 00:06:51:00 Segment 2 Turk uses a diagram with moveable pieces to show the mechanism of sensitisation to an invading body. He describes all immune reactions as being like a reflex arc which becomes complicated as more physiological systems become involved. Next he shows an illustration of a lymph node and a histogram of a lymph node with depleted T-lymphocytes. Time start: 00:06:51:00 Time end: 00:10:26:00 Length: 00:03:35:00 Segment 3 Turk shows an illustration of a lymph node with a proliferation of T-lymphoyctes, then autoradiographs of the same. He refers to a diagram comparing cell-mediated immunity with humoral antibody production and a graph detailing the pieaks of lymphocyte proliferation. After this, he returns to the diagram with moveable pieces and makes it more complex. Time start: 00:10:26:00 Time end: 00:17:10:00 Length: 00:06:44:00 Segment 4 Turk shows slides and graphs relating to how macrophages function in tissue culture. He describes their function in detail. Time start: 00:17:10:00 Time end: 00:20:04:00 Length: 00:02:54:00
Credits: Presented by Professor John Turk, Institute of Basic Medical Science. Produced by Peter Bowen.
Further information: This video is one of more than 120 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.
Keywords: Dermatology; Histocompatibility Antigens Class II; Allergy and Immunology; Immunity, Cellular; Hypersensitivity; T-Lymphocytes
Locations: United Kingdom; England; London; University of London
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