Description: Segment 1 Hall introduces the subject and shows close-up photographs of females with Graves' disease, pointing out the distinguishing features, in particular the eye signs and enlargement of the thyroid gland. He then refers to a table listing different kinds of mechanism which stimulate hyperthyroidism - these can be from a primary thyroid abnormality or from thyroid-stimulating hormones. However, in Graves' disease, thyroid stimulating hormones are often reduced, leading Hall into the subject of why patients with Graves' disease should have hyperthyroidism. He describes how researchers sought to find a long-acting thyroid stimulator (LATS) to account for this. Hall hands over to Smith. Time start: 00:00:00:00 Time end: 00:06:31:00 Length: 00:06:31:00 Segment 2 Smith continues to discuss the search for a plausible LATS to account for the hyperthyroidism of Graves' disease. He refers to studies at a molecular level using diagrams. Using a large mobile diagram of the thyroid cell surface, he shows where the likely receptor sites for a LATS interaction might be. Smith hands back to Hall. Time start: 00:06:31:00 Time end: 00:10:40:00 Length: 00:04:09:00 Segment 3 Hall uses an animated illustration of a mouse to explain how a LATS protector assay might function - it is largely agreed that it is a LATS protector assay which stimulates the thyroid gland in Graves' disease. Smith refers to a series of tables listing various assays chemically developed to stimulate the thyroid gland. Hall hands over to Smith Time start: 00:10:40:00 Time end: 00:14:19:00 Length: 00:03:39:00 Segment 4 Smith refers again to the earlier large mobile diagram of the thyroid cell surface, then over a series of graphs plotting different types of thyroid stimulators. It is apparent that many of the thyroid stimulating antigens present in patients with Graves' disease are also present in patients without the condition. Hall takes over again. Time start: 00:14:19:00 Time end: 00:19:56:00 Length: 00:05:37:00