Progress in prevention
digital file Colour Sound 1970 13:11
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Summary: Vaccination has developed considerably since Jenner's time. With a wealth of laboratory and pharmaceutical manufacturing footage this film explains the use of tissue cultures in the production of vaccines, with special reference to the production and quality of control of the Wellcome produced rubella vaccine Almovax. 2 segments.
Title number: 18119
LSA ID: LSA/21276
Description: Segment 1 The Wellcome Research Laboratories in Beckenham, Kent, are seen. John Beale, the Head of Wellcome Foundation's Biological Division, describes to the camera Edward Jenner's work on vaccinations and how his discoveries have been built on by subsequent researchers. The narrator explains the history of vaccination development, including the use of chick embryos, monkey kidneys and other animal tissues and finally tissue cultures of human origin. Scientists are seen researching and developing the tissue cultures, including harvesting chick embryos. The narrator explains the history of the use of human tissue cultures in vaccinations, including the development of the WI-38 human diploid cell line developed by Dr Hayflick in the late 1950s from lung tissue. This is the culture used by Wellcome to make their rubella vaccine, Almovax. The process of developing the vaccine is shown. The cells are grown and observed. Time start: 00:00:00:00 Time end: 00:06:27:06 Length: 00:06:27:06 Segment 2 A scientist observing the tissue culture's growth explains what he is doing. Samples of the cell strain are injected into hamsters to check that no tumour-forming characteristics exist. The tissue cultures are also tested on monkey kidneys. The rubella virus is incubated. The process of producing the vaccine is shown. The raw vaccine is further tested. A scientist explains how to test the vaccine using an electron microscope. The vaccine is packaged and freeze dried. The narrator explains that this is the first vaccine that Wellcome have produced from human deployed cells, but that soon an oral polio vaccine will be produced using this method. Time start: 00:06:27:06 Time end: 00:13:11:20 Length: 00:06:44:14
Credits: Narrated by Martin Jarvis, photographed by Derek Waterman, edited by Michael Foale, produced by Ann Mulligan and written and directed by John Lawrence. Filmed at the Wellcome Research Laboratories, Beckenham.
Keywords: Rubella; Pharmaceutical industry; Vaccination
Locations: United Kingdom; England; Kent; Beckenham; Wellcome Research Laboratories
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