Description: Segment 1 Prof. Humble introduces the subject and talks about the current interest in the use of bone marrow transplantation to treat severe aplastic anaemia and immune diseases of infancy and early childhood. He gives a history of research in this area, beginning with Neumann's research in 1868. An illustration shows where bone marrow can be taken for transplantation. He discusses the importance of the totipotential stem cell. Diagrams explain stem cell function. An electron micrograph of a stem cell is seen, and Humble discusses the stem cell. Time start: 00:00:00:00 Time end: 00:04:15:00 Length: 00:04:15:00 Segment 2 Humble then discusses trials using cancer patients' bone marrow to treat them after radiation. A graph shows the single successful case of the study. The graph details the patient's recovery, which Humble also describes. He talks about residual immunity, which must be destroyed to allow grafts to take. A table lists information on the methods of destroying residual immunity. He also discusses the danger of graft-versus-host disease. A table lists the syndromes of this disease, and two pictures of people suffering from the disease are seen. Time start: 00:04:15:00 Time end: 00:09:27:00 Length: 00:05:12:00 Segment 3 Humble lists the conditions needed for bone marrow transplantation. A photograph of a baby with SCID is seen, along with a list of symptoms of the condition. Further photographs of the little girl are seen as she recovers. Humble describes the bone marrow transplants from her brother. Time start: 00:09:27:00 Time end: 00:14:05:20 Length: 00:04:38:20 Segment 4 Next, Humble describes the steps taken to set up a bone marrow transplant. Animated diagrams show the steps. Humble describes the decontamination process of the patient, and footage of a boy in a sterile plastic environment is seen. Time start: 00:14:05:20 Time end: 00:18:24:00 Length: 00:04:18:05 Segment 6 Next, Humble talks about how to support the patient in the post-graft period. He then talks about future developments and what he hopes will improve in this field. This includes treatment for congenital haemolytic disease. Time start: 00:23:06:00 Time end: 00:27:59:02 Length: 00:04:53:02